Open your flies first, get them out of the way, then start working on the spiders. I always think its best to get the more awkward things gone first.
No empty nests, even better.
Once you just need to get crops together, make combinations and plan moves ahead to get extra points on them. You have a nice clear board that should allow you to do this.
Remember you only need two types of crops, but clearing 5 of any will help.